RESEARCH INTERESTS

Electroneutral Ion Transport: Na/H and K/H Exchange
NHE1 Structure Function Relationships
Hypoxic and Ischemic Cytotoxicity
Cell Volume and pH Regulation
Membranes and Transport
Red blood cells
Tumor Growth and Proliferation

SOCIETY AFFILIATIONS

Association of Chairs of Departments of Physiology
American Physiological Society
Biophysiological Society
Society for General Physiology
Red Blood Cell Club
Mt. Desert Island Biological Laboratories

SELECTED PUBLICATIONS

1973 Cala, Peter M. Volume regulation of winter flounder (Pseudopleuronectes Americanus) red blood cells. Bulletin, Mt. Desert Island Biological Laboratories, 13:20-25.

1976 Benos, J. Dale, Sidney A. Simon, Lazaro J. Mandel and Peter M. Cala. Effect of amiloride and some of its analogues on cation transport in isolated frog skin and thin lipid Membranes. Journal of General Physiology 68:43-63. PubMed Link

1977 Cala, Peter M. Volume regulation by flounder red blood cells in anisotonic media. Journal of General Physiology 69:537-552.

1978 Cala, Peter M. Neale Cogswell and Lazaro J. Mandel. Binding of 3H-Ouabain to split frog skin: The role of the Na-K ATPase in the generation of short circuit current. Journal of General Physiology 71:347-367. PubMed Link

1980 Cala, Peter M. Volume regulation by Amphiuma red blood cells: The membrane potential and its implications regarding the nature of the ion flux pathways. Journal of General Physiology 76:683-708. PubMed Link

1982 Cala, Peter M., Jens G. Nørby and Daniel C. Tosteson. Effects of the plant alkaloid sanguinarine on cation transport by human red blood cells and lipid bilayer membranes. Journal of Membrane Biology 64:23-31. PubMed Link

1983 Cala, Peter M. Volume regulation by red blood cells: Mechanisms of ion transport. Molecular Physiology 4:33-52.

1983 Cala, Peter M. Volume regulation by Amphiuma red blood cells: The role of Ca+2 as a modulator of the alkali metal/proton exchanger. Journal of General Physiology 82:761-784. PubMed Link

1985 Cala, P.M. Volume regulation by Amphiuma red blood cells: Characteristics of volume-sensitive K/H and Na/H exchange. Journal of Molecular Physiology 8:199-214.

1988 Cala, P.M., S.E. Anderson and E.J. Cragoe, Jr. Na/H exchange-dependent cell volume and pH regulation and disturbances. Comparative Biochemistry and Physiology 90A:551-555. PubMed Link

1990 Anderson, S.E., E. Murphy, C. Steenbergen, R.E. London, and P.M. Cala. Na-H exchange in myocardium: effects of hypoxia and acidification on Na and Ca. American Journal of Physiology 259 (Cell Physiol. 28):C940-C948. PubMed Link

1994 Cala, P.M. and H.M. Maldonado. pH regulatory Na/H exchange by Amphiuma red blood cells. J. Gen Physiol. 103:1035-1054. PubMed Link

1999 McLean, LA, S. Zia, F. A. Gorin, and P. M. Cala. Cloning and expression of the Na+/H+ exchanger from Amphiuma RBCs: resemblance to mammalian NHE1. American Journal of Physiology 276 (Cell Physiol. 45): C1025-C1037. PubMed Link

2000 McLean LA, J. Roscoe, N. K. Jorgensen, F. A. Gorin, and P. M. Cala. Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes. American Journal of Physiology 278: (Cell Physiol. 47) C676-C688. PubMed Link

2000 Ho HS, H. Liu, P.M. Cala and S.E. Anderson. Hypertonic perfusion inhibits intracellular Na and Ca accumulation in hypoxic myocardium. American Journal of Physiology 278: (Cell Physiol. 47) C953-C964. PubMed Link

2003 Stine F. Pedersen, Scott A. King, Robert R. Rigor, Zhenpeng Zhuang, Jaimie M. Warren, and Peter M. Cala. Molecular cloning of NHE1 from winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A. Am J Physiol Cell Physiol 284: C1561-C1576. PubMed Link

2005 Anderson, S.E., D. M. Kirkland, A. Beyschau, and P.M. Cala. Acute effects of 17ß-estradiol on pH, Na, and Ca and ischemia/reperfusion injury. Am J. Physiol: Cell Physiol. 288: C57-C64. PubMed Link

2006 Pedersen, S.F., M.E. O’Donnell, S.E. Anderson and P.M. Cala. Physiology and pathophysiology of Na+/H+ exchange and Na+-K+-2Cl- cotransport in the heart, brain and blood. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291: R1-R25. PubMed Link

2006 Holt, M.E., S.A. King, P.M. Cala and S.E. Pedersen. Regulation of the Pleuronectes americanus Na+/H+ exchanger by osmotic shrinkage, beta-adrenergic stimuli, and inhibition of the Ser/Thre protein phosphatases. Cell. Biochem. Biophys. 45: 1-18. PubMed Link

2007 King, S. A., E.B. Nygaard , R.R. Rigor R.R, S. F. Pedersen, and P. M. Cala. NHE1 inhibition by amiloride- and benzoyl guanidine-type compounds: inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity. J Biol Chem. 282(27): 19716-27. Epub 2007 May 10. PubMed Link


Physiology and Membrane Biology
Copyright © UC Regents, Davis Campus.
All rights reserved.