RESEARCH INTERESTS

Functional modulation of ion channels by post-translational mechanisms such as protein phosphorylation, dephosphorylation, lipid modification and nitrosylation Molecular mechanisms responsible for ion channel modulation Signaling pathway of nitric oxide-mediated modulation of KATP channel Role of KATP channels in neuronal ischemia preconditioning Function of GABA receptor-ion channel complexes in experimental models of epilepsy

SELECTED PUBLICATIONS

1987		Lin, A.M.Y., Pan, C.M., Lin, Y.F., Kuo, J.S. and Chai, C.Y. A cardioinhibitory area in the midbrain central tegmental field of cats. Brain Res. Bull. 18: 699-707.
1988		Chai, C.Y., Lin, Y.F., Lin, A.M.Y., Pan, C.M., Lee, E.H. and Kuo, J.S. Existence of a powerful inhibitory mechanism in the medial region of caudal medulla--with special reference to the paramedian reticular nucleus. Brain Res. Bull. 20: 51-28.
1990		Chai, C.Y., Lin, Y.F., Wang, H.Y., Wu, W.C., Yen, C.T., Kuo, J.S. and Wayner, M.J. Inhibition of spinal reflexes by paramedian reticular nucleus. Brain Res. Bull. 25: 581-588.
1991		Yen, C.T., Hwang, J.C., Su, C.K., Lin, Y.F., Yang, J.M. and Chai, C.Y. Differential actions of the median region of caudal medulla on autonomic nerve activities. Clin. Exp. Pharmacol. Physiol. 18: 743-751.
1992		Chai, C.Y., Wu, W.C., Wang, S., Su, C.K., Lin, Y.F., Yen, C.T., Kuo, J.S. and Wayner, M.J. Coexistence of autonomic and somatic mechanisms in the pressor areas of medulla in cats. Brain Res. Bull. 29: 15-26.
1994		Lin, Y.F., Browning, M.D., Dudek, E.M. and Macdonald, R.L. Protein kinase C enhances bovine 1 1 2L GABAA receptor whole-cell currents expressed in L929 fibroblasts. Neuron 13: 1421-1431.
1996		Lin, Y.F., Angelotti, T.P., Dudek, E.M., Browning, M.D. and Macdonald, R.L. Protein kinase C phosphorylation of the 1 and 2L subunits of the GABAA receptor enhances whole-cell currents expressed in L929 fibroblasts. Mol. Pharmacol. 50: 185-195.
2000		Lin, Y.F., Jan, Y.N. and Jan, L.Y. Regulation of ATP-sensitive potassium channel function by protein kinase A-mediated phosphorylation in transfected HEK293 cell. EMBO J. 19: 942-955.
2000		Minor, D.L., Lin, Y.F., Mobley, B.C., Avelar, A., Jan, Y.N., Jan, L.Y. and Berger, J.M. The polar T1 interface is linked to conformational changes that open the voltage-gated potassium channel. Cell 102: 657-670.
2001		Ma, D., Zerangue, N., Lin. Y.F., Collins, A., Yu, M., Jan, Y.N. and Jan, L.Y. Role of ER export signals in controlling surface potassium channel numbers. Science 291: 316-319.
2001		Yi, B.A., Lin, Y.F., Jan, Y.N. and Jan, L.Y. Yeast screen for constitutively active mutant G protein-activated potassium channels. Neuron 29: 657-667.
2001		Yi, B.A., Minor, D.L., Lin, Y.F., Jan, Y.N. and Jan, L.Y. Controlling potassium channel activities: interplay between the membrane and intracellular factors. Proc. Natl. Acad. Sci. USA 98: 11016-11023.
2004		Bichet, D., Lin, Y.F., Ibarra, C.A., Huang, C.S., Yi, B.A., Jan, Y.N. and Jan, L.Y. Evolving potassium channels via yeast selection reveals structural elements important for selectivity. Proc. Natl. Acad. Sci. USA 101: 4441-4446, 2004.
2004		Lin, Y.F., Raab-Graham, K., Jan, Y.N., and Jan, L.Y. Nitric oxide stimulation of ATP-sensitive potassium channels: Involvement of Ras/MAPK kinase pathway and contribution to neuroprotection. Proc. Natl. Acad. Sci. USA 101: 7799-7804, 2004 (YFL as corresponding author).

2007		Mao, X., Chai, Y. and Lin, Y.F. Dual regulation of ATP-sensitive potassium channels by caffeine. Am. J. Physiol. Cell Physiol. 292: C2239-C2258. Epub 2007 Feb 15.

2007		Misaki, N., Mao, X., Lin, Y.F., Suga, S., Li, G.H., Liu, Q., Chang, Y., Wang, H, Wakui, M. and Wu, J. Iptakalim, a cardiovascular KATP channel opener, closes rat pancreatic beta-cell KATP channels and its molecular basis. J. Pharmacol. Exp. Ther. 322: 871-878. Epub 2007 May 23.
2008		Lin, Y.F., and Chai, Y. Modulation of the ATP-sensitive potassium channel by extracellular signal-regulated kinase-mediated phosphorylation. Neuroscience . doi: 10.1016/j. neuroscience. 2008.01.003 (Available online 9 January 2008).
2008		Chai, Y. and Lin, Y.F. Dual regulation of he ATP-sensitive potassium channel by activation of cyclic GMP-dependent protein kinase. Pflugers Archiv-European J. Physiol. doi: 10.1007/s00424-008-0447-z (Published online 30 January 2008).